In-vitro Biodegradation Rate

Form	Description	Half-life, Mass	Half-life, Mw (Mn)	Reference
Poly(Glycolic acid)
Suture	Dia. 0.35 mm	55 days	Not stated	Chu et al 1981
Microfiber	Dia. 13 um Mw 69 kD	28 days	Not stated	Freed et al 1994
Nanofiber	Dia. 380 nm MW 14 - 20 kD	12 days	Not stated	Park et al 2006
Nanofiber	Dia. 310 nm Mw 14 - 20 kD	16 days	Not stated	You et al 2005
Poly-DL-lactic acid (PDLLA)
Electrospun fibrous membrane	Thickness 150 um Mw 53 kD	>> 10 weeks	Mw, >> 10 weeks	Cui et al 2008
Rod	Mw 65 kD	10 weeks	Not stated	Li et al 1990a
Porous Rod	Height 10 mm, Dia. 10 mm Porosity 87% Mw 834 g/mol	Not stated	(11.1 weeks)	Wu et al 2004
Plate	Thickness 2 mm Mw 43 kD	12 weeks	6 weeks	Grizzi et al 1995
Film	Thickness 300 um Mw 67 kD	Not stated	12 weeks	Grizzi et al 1995
Film	Thickness 100 um Mw 78 kD	Not stated	9 weeks	Cui et al 2006
Film	Thickness 150 um Mw 53 kD	>> 10 weeks	Mw, 7 weeks	Cui et al 2008
Poly(Glycolic)-Poly(Lactic Acid) (85:15) (PLGA)
Porous Rod	Height 10 mm, Dia. 10 mm Porosity 87% Mw 577 g/mol	Not stated	(4.0 weeks)	Wu et al 2004
Poly(Glycolic)-Poly(Lactic Acid) (75:25) (PLGA)
Rod	Mw 51 kD	21 days	Not stated	Li et al 1990b
Porous Rod	Height 10 mm, Dia. 10 mm Porosity 87% Mw 324 g/mol	Not stated	(2.2 weeks)	Wu et al 2004
Nanofiber	Dia. 550 nm Mw 123 kD	>> 8 weeks	> 8 weeks	Shin et al 2006
Nanofiber	Dia. 484 nm Mw 80 kD	> 80 days	> 80 days	Dong et al 2010
Poly(Glycolic)-Poly(Lactic Acid) (50:50) (PLGA)
Thin film	Thickness: 0.5 mm	21 days	21 days	Reed and Gildings 1981
Nanofiber	Dia. 760 nm Mw 108 kD	25 days	40 days	You et al 2005b
Nanofiber	Dia. 550 nm Mw 98 kD	>> 8 weeks	4 weeks	Shin et al 2006
Poly(L-lactic acid)
Porous scaffold	Mw 177,000	> 40 weeks	33 weeks	Gong et al 2007
Film	Thickness: 100 um Mw 284, 000	>> 52 weeks	> 52 weeks	Freier et al 2002
Poly(e-caprolactone)
Film	10 x 5 mm, 100 um thickness Mw 641,000	>> 52 weeks	56 weeks	Freier et al 2002
Nanofiber	Dia. 196 nm Dia. 250 nm Dia. 300 nm Dia. 689 nm Mw 84,387	Not stated	>> 6 months	Bolgen et al 2005
Poly(D,L-lactide)-poly(ethylene glycol)
Film	150 um Mw 51 kDa	>> 10 weeks	7 weeks	Cui et al 2008
Electrospun fibrous membrane	150 um Mw 51 kDa	>> 10 weeks	> 8 weeks	Cui et al 2008

▼ Reference

Bolgen N, Menceloglu Y Z, Acatay K, Vargel I, Piskin E (2005) In vitro and in vivo degradation of non-woven materials made of poly(e-caprolactone) nanofibers prepared by electrospinning under different conditions. J. Biomater. Sci. Polymer Edn 16 pp. 1537
Chu C C (1981) Hydrolytic Degradation of Polyglycolic Acid - Tensile-Strength and Crystallinity Study. Journal of Applied Polymer Science, 26 pp. 1727-1734.
Cui W G, Li X H, Zhu X L, Yu G, Zhou S B, Weng J (2006) Investigation of drug release and matrix degradation of electrospun poly(DL-lactide) fibers with paracetanol inoculation. Biomacromolecules, 7 pp. 1623-1629.
Cui W, Li X, Zhou S, Weng J. Degradation patterns and surface wettability of electrospun fibrous mats. Polymer Degradation and Stability 2008; 93: 731.
Dong Y X, Yong T, Liao S, Chan C K, Ramakrishna S (2010) Distinctive degradation behaviors of electrospun PGA, PLGA and P(LLA-CL) nanofibers cultured with/without porcine smooth muscle cells. Tissue Engineering Part A 16 pp. 283.
Freed L E, Vunjaknovakovic G, Biron R J, Eagles D B, Lesnoy D C, Barlow S K, Langer R (1994) Biodegradable Polymer Scaffolds for Tissue Engineering. Bio-Technology, 12 pp. 689-693.
Freier T, Kunze C, Nischan C, Kramer S, Sternberg K, SaB M, Hopt U T, Schmitz K P (2002) In vitro and in vivo degradation studies for development of a biodegradable patchbased on poly(3-hydroxybutyrate). Biomaterials 23 pp. 2649
Gong Y, Zhou Q, Gao C, Shen J (2007) In vitro and in vivo degradability and cytocompatibility of poly(L-lactic acid) scaffold fabricated by a gelatin particle leaching method. Acta Biomaterialia 3 pp. 531.
Grizzi I, Garreau H, Li S, Vert M (1995) Hydrolytic Degradation of Devices Based on Poly(Dl-Lactic Acid) Size-Dependence. Biomaterials, 16 pp. 305-311.
Li S M, Garreau H, Vert M (1990a) Structure Property Relationships in the Case of the Degradation of Massive Aliphatic Poly-(Alpha-Hydroxy Acids) in Aqueous-Media .1. Poly(Dl-Lactic Acid). Journal of Materials Science-Materials in Medicine, 1 pp. 123-130.
Li S M, Garreau H, Vert M (1990b) Structure Property Relationships in the Case of the Degradation of Massive Poly(Alpha-Hydroxy Acids) in Aqueous-Media .2. Degradation of Lactide-Glycolide Copolymers - Pla37.5Ga25 and Pla75Ga25. Journal of Materials Science-Materials in Medicine, 1 pp. 131-139.
Park K E, Kang H K, Lee S J, Min B M, Park W H (2006) Biomimetic nanofibrous scaffolds: Preparation and characterization of PGA/chitin blend nanofibers. Biomacromolecules, 7 pp. 635-643.
Reed A M, Gilding D K (1981) Biodegradable Polymers for Use in Surgery - Poly(Glycolic)-Poly(Lactic Acid) Homo and Co-Polymers .2. Invitro Degradation.Polymer, 22 pp. 494-498.
Shin H J, Lee C H, Cho I H, Kim Y J, Lee Y J, Kim I A, Park K D, Yui N, Shin J W (2006) Electrospun PLGA nanofiber scaffolds for articular cartilage reconstruction: mechanical stability, degradation and cellular responses under mechanical stimulation in vitro. Journal of Biomaterials Science-Polymer Edition, 17 pp. 103-119
Wu L, Ding J. In vitro degradation of three-dimensional porous poly(d,l-lactide-coglycolide)scaffolds for tissue engineering. Biomaterials 2004; 25: 5821.
You Y, Min B M, Lee S J, Lee T S, Park W H (2005b) In vitro degradation behavior of electrospun polyglycolide, polylactide, and poly(lactide-co-glycolide). Journal of Applied Polymer Science, 95 pp. 193-200.

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